Harukoi Otome revolves around the protagonist Akihito Hayasaka, a male high school student. The high school he attends at St. Francesca Academy used to be an all-girls school, but today it houses both sexes, although the number of girls is still predominant. Akihito’s younger sister (Umi Hayasaka) and his childhood friend (Yuika Serizawa) are also students there. Akihito meets many girls there, and becomes close friends with some of them.